LE220-plus Focused-ultrasonicator

CovarisSKU: COV-500569



  • Treatment Power: 0.1 to 250 W Avg. Incident Power, 2.5 to 500 W PIP
  • Sample Processing Capacity: 1 to 8 tubes processing


The LE220-plus Focused-ultrasonicator is a scalable, automated high-performance sample preparation instrument. With automated water works to optimize user-to-user reproducibility and remote set-up and scheduling to maximize laboratory efficiency, the LE220-plus is designed for integration with high-throughput laboratory automation. Includes integrated AFA ultraCUBE water chiller and the water conditioning module.


Specifications :

Technical Specification Description
Primary Applications Cell lysis: mammalian, bacterial, yeast, cfDNA Extraction from Plasma, DNA Extraction from Dried Blood Spots, DNA/RNA/Chromatin Shearing, DNA/RNA/Total NA/Protein Extraction from FFPE, Tissue lysis and extraction
Treatment Power 0.1 to 250 W Avg. Incident Power, 2.5 to 500 W PIP
Part Number COV-500569
Power Requirements 100-240 VAC 500 VA, 50-60Hz
Operating Environment Ambient temperature: 19 °C to 25 °C (66 °F to 77 °F) Relative humidity: 30% to 70%
Operating Temperature 5 °C to 40 °C
Safety Complies with Low Voltage Directive 2006/95/EC. Certified to IEC/EN/UL 61010-1:2004 “Safety Requirements for Electrical Equipment for Measurement, Control, and Laboratory Use, Part1: General Requirements
Regulatory Labeling CE, ETL Mark (for Product Safety), WEEE
SonoLab Version SonoLab 8
Operating System Windows 10
WCS Yes, WCS 2.0 (Included with system)
Chiller ThermoCube (included with system)
Sample Processing Capacity 1 to 8 tubes parallel processing
Recommended Batch Size 1 to 96 samples
Covaris Consumables Individual microTUBEs, 8 microTUBE strips (rack required), 96 microTUBE plate, 8 AFA-TUBE TPX Strip, 96 AFA-TUBE TPX plate (with RFID), miniTUBEs, milliTUBEs
Upgrade Potential Yes
Associated Accessories L-Series Accessories


Key Features:

  • Fully automated workflow
  • Powered by AFA-energetics ®
  • Multiple isothermal energy delivery modes



  • Accurate, reproducible, and robust sample preparation
  • Tunable, non-contact processing
  • Simplify highly complex workflows


Quick Guides::

Quick Guide: DNA Shearing with LE220-plus/LE220R-plus/LE220Rsc

RNA Shearing with S, E, and LE-Series Focused-ultrasonicators

TruSight Tumor 170 DNA Shearing Quick Guide



E220 & LE220 (-plus, R-plus, Rsc) Setup & Instruction Manual

LE220 (-plus, R-plus, and Rsc) Setup & Instruction Manual



High Performance Multiplexed Target Enrichment Sequencing from FFPE Tissues



Covaris Automation Platform Solutions for Pre-analytical Sample Preparation

LE220-plus Focused-ultrasonicator


Application Notes:

AFA-energetics®- Mediated RNA Extraction from Yeast

Mediated RNA Extraction from Yeast...... Learn More

AFA-energetics®-Mediated DNA Extraction from Yeast and Bacteria Using Scanning in a Labcyte 384-well Plate

This document describes the optimized AFA-energetics dose to lyse and extract DNA from S. cerevisiae, E. coli, & L. monocytogenes using a proprietary scanning method... Learn More

Covaris Shearing Guide for 500 Base Pairs using the 96 AFA-TUBE TPX Plate

This application note provides additional support for the current AFA-TUBE TPX shearing protocol to achieve 500 base pair (bp) DNA fragments using AFA® on the... Learn More

High-Throughput, Low Volume gDNA Extraction from Whole Blood Enabled by Covaris Adaptive Focused Acoustics® (AFA®) and AFA-TUBE® TPX

Extraction of gDNA from whole blood is the first step in multiple translational research and molecular diagnostics applications, such as next-generation sequencing, multiplex PCR, qPCR,... Learn More

Lysis and Extraction of Biomolecules from Eukaryotic and Prokaryotic Cells Powered by AFA-energetics®

Covaris developed a novel automatable approach for the extraction of biomolecules from microbial samples for analysis with mass spectrometry technologies using Adaptive Focused Acoustics® technology....... Learn More

Lysis and High Molecular Weight DNA Extraction from Eukaryotic and Prokaryotic Cells Powered by AFA-energetics®

This application note describes an automatable approach to cell lysis and extraction of high molecular weight DNA from microbial samples, which can be sequenced with... Learn More

Magnetic Bead-based Clean-up Using AFA-energetics®

When precisely tuned, this stream of Covaris Adaptive Focused Acoustic energy enables DNA shearing precisely and reliably to desired fragment sizes, in addition to gentle... Learn More

truXTRAC® FFPE RNA Extraction and Purification - Quality Metrics for Clinical Applications Powered by Adaptive Focused Acoustics® (AFA®)

FFPE RNA Extraction...... Learn More

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