ME220 Focused-ultrasonicator

CovarisSKU: COV-500506



The ME220 Focused-ultrasonicator is the multi-sample, multi-application benchtop sample preparation solution for every lab. Capable of 1 to 8 sample batch processing at the bench-top, this compact, easy-to-use system enables precise and accurate results with AFA-energetics®.




Technical Specification Description
Primary Applications Cell lysis: mammalian, bacterial, yeast, cfDNA Extraction from Plasma, DNA Extraction from Dried Blood Spots, DNA/RNA/Chromatin Shearing, DNA/RNA/Total NA/Protein Extraction from FFPE, Tissue lysis and extraction
Treatment Power 20 W Avg. Incident Power, 75 W PIP
Part Number 500506
Power Requirements 100-240 VAC 500 VA, 50-60Hz, 5 Amp Slo-Blow Fuse
Operating Environment Ambient temperature: 19 °C to 25 °C (66 °F to 77 °F) Relative humidity: 30% to 70%
Operating Temperature Programmable +6.0 °C to +40.0 °C
Safety Complies with Low Voltage Directive 2006/95/EC. Certified to IEC/EN/UL 61010-1:2004 “Safety Requirements for Electrical Equipment for Measurement, Control, and Laboratory Use, Part1: General Requirements
Regulatory Labeling CE, ETL Mark (for Product Safety), WEEE
SonoLab Version SonoLab 8
Operating System Windows 10
Chiller Stand-alone benchtop
Sample Processing Capacity Single tube processing
NGS Sample Volumes 15 to 130 µl
Recommended Batch Size 1 to 8 samples
Covaris Consumables microTUBE 8 strip, milliTUBE, miniTUBE (rack required)
Upgrade Potential Yes
Associated Accessories ME220 Accessories


Key Features

  • Isothermal process
  • Small, compact footprint
  • Non-contact, closed vessel
  • Flexible sample processing volume
  • Highly reproducible results
  • Automatable
  • Sample tracking with 2D barcoded consumables
  • Operates at 500 kHz (Ultrasonic Range)
  • Calibrated to NIST traceable standards



  • No heat-induced bias, high sample recovery
  • Fits on any bench top
  • No cross-contamination, aerosols, or clean-up
  • 15 μl to 1 ml
  • Minimal post-process QC required
  • Sample vessels compatible with liquid handling robots
  • Traceable sample identification
  • Beyond audible range – no discomfort to operators
  • Optimized protocols available and transferable


Quick Guides:

Quick Guide: DNA Shearing with ME220 Focused-ultrasonicator

RNA Shearing with M220 and ME220 Focused-ultrasonicators

TruSight Tumor 170 DNA Shearing Quick Guide



ME220 User Manual

Replacing the ME220 Quick Disconnect Insert

Replacing the ME220 Quick Disconnect Cap

Replacing the ME220 Particle Filter Element and Gasket



M-Series Focused-ultrasonicators


Application Notes:

AFA-based RNA Extraction from Mycobacteria smegmatis

RNA Extraction ... Learn More

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