E220 Focused-ultrasonicator

CovarisSKU: COV-500239



  • Treatment Power: 100 W Avg. Incident Power
  • Sample Processing Capacity: Single tube processing
  • NGS Sample Volumes: 15 to 130 µl

The E220 Focused-ultrasonicator enables multi-sample batch preparation, capable of processing a wide range of sample types and volumes. The E220 may be programed to process from 1 to 96 samples in a single batch.



Technical Specification Description
Primary Applications Cell lysis: mammalian, bacterial, yeast, cfDNA Extraction from Plasma, DNA Extraction from Dried Blood Spots, DNA/RNA/Chromatin Shearing, DNA/RNA/Total NA/Protein Extraction from FFPE, Tissue lysis and extraction
Treatment Power 100 W Avg. Incident Power
Part Number COV-500239
Power Requirements 100-120, 200-240 V~ 50-60Hz, 500 VAC
Operating Environment Ambient temperature: 19 °C to 25 °C (66 °F to 77 °F) Relative humidity: 30% to 70%
Operating Temperature 0.5 °C to 55.0 °C
Safety Complies with Low Voltage Directive 2006/95/EC. Certified to IEC/EN/UL 61010-1:2004 “Safety Requirements for Electrical Equipment for Measurement, Control, and Laboratory Use, Part1: General Requirements
Regulatory Labeling CE and ETL Mark
SonoLab Version SonoLab 7
Operating System Windows 10
Chiller Chiller/heater re-circulating system-Not included,sold separately
Sample Processing Capacity Single tube processing
NGS Sample Volumes 15 to 130 µl
Recommended Batch Size 1 to 96 samples
Covaris Consumables microTUBE 8-strip (rack required), microTUBE 96 plate
Upgrade Potential No
Associated Accessories E220 Accessories



Key Features

  • Isothermal processing
  • Non-contact, closed vessel
  • Precisely controlled and adjustable energy delivery
  • Automation ready
  • Multi-sample capability
  • Broad sample volume range



  • No heat damage, higher recovery
  • No cross contamination, no aerosols, no clean up
  • Standardized processes, highly reproducible
  • Integrates into customers’ sample processing workflow
  • Higher productivity, less operator intervention
  • One instrument for multiple applications


Quick Guides:

DNA miniTUBE – Blue for 220 Series

DNA miniTUBE – Clear for 220 Series

DNA miniTUBE – Red for 220 Series

DNA Shearing Quick Guide: microTUBE-15 with S220/E220 Focused-ultrasonicator.

DNA Shearing with microTUBEs (<1.5kb fragments) S220/E220

Quick Guide: DNA Shearing with E220 Focused-ultrasonicator .

RNA Shearing with M220 and ME220 Focused-ultrasonicators

TruSight Tumor 170 DNA Shearing Quick Guide



E/LE220 Series SonoLab 7 User Manual

E-series User Manual



E220 / E220x (E-Series) High Performance Multi-Sample Preparation System


Formulation and Drug Delivery Breakthrough processing for poorly soluble API’s



Optimizing a Dual Fixation Protocol to Study Protein Complexes Binding to Chromatin in vivo

A New Effective Method for the Disruption of Pseudomonas aeruginosa Biofilms Using Adaptive Focused Acoustics(AFA)


Application Notes:

Automated NGS Library Preparation with Beckman Biomek FXP and Covaris E220

Key parameters for high quality library preparation are homogeneity of the library insert size and un-biased fragmentation profile, which is why Covaris AFA technology was.... Learn More

Optimizing a Dual Fixation Protocol to Study Protein Complexes Binding to Chromatin in vivo

This application note provides shearing profiles, evaluates epitope integrity each shearing time and ChIP-qPCR results obtained using single step formaldehyde fixation and dual crosslinking protocol.... Learn More

Streamlined Ultra Low Sample Input and Processing Volume Chromatin Shearing Protocols for Fly Embryos and Mammalian Cell Lines

These protocols have been optimized for both mammalian cell lines and fly embryos and reliably fragment chromatin in low volumes from down to 10,000 mammalian.... Learn More

Transitioning from custom amplicon-based parallel sequencing to hybrid capture-based sequencing in molecular pathology routine diagnostics

Molecular Pahology.... Learn More


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