LE220R-plus Focused-ultrasonicator

CovarisSKU: COV-500578



  • Treatment Power: 0.1 to 250 W Avg. Incident Power, 2.5 to 500 WPIP
  • Sample Processing Capacity: 1 to 8 tubes parallel processing
  • NGS Sample Volumes: 5 to 320 µl

The LE220R-plus is the robotic version of the LE220-plus with an opening for a robotic arm to grip the sample plate with motion sensor for safety. Column of 8 to full plate processing in a single batch with scheduling system set-up for degas and chiller and automated water level adjustments. The LE220R-plus is designed for integration with high throughput laboratory automation. Includes integrated AFA ultraCUBE water chiller and the water conditioning module.




Technical Specification Description
Primary Applications cfDNA Extraction from Plasma, DNA Extraction from Dried Blood Spots, DNA/RNA/Chromatin Shearing, DNA/RNA/Total NA/Protein Extraction from FFPE, Cell Lysis, High Molecular Weight DNA Extraction
Treatment Power 0.1 to 250 W Avg. Incident Power, 2.5 to 500 WPIP
Part Number COV-500578
Power Requirements 100-240 VAC 500 VA, 50-60Hz
Operating Environment Ambient temperature: 19 °C to 25 °C (66 °F to 77 °F) Relative humidity: 30% to 70%
Operating Temperature 5 °C to 40 °C
Safety Complies with Low Voltage Directive 2006/95/EC. Certified to IEC/EN/UL 61010-1:2004 “Safety Requirements for Electrical Equipment for Measurement, Control, and Laboratory Use, Part1: General Requirements
Regulatory Labeling CE, ETL Mark (for Product Safety), WEEE
SonoLab Version SonoLab 8
Operating System Windows 10
WCS Yes, WCS 2.0 (Included with system)
Chiller UltraCube (included with system)
Sample Processing Capacity 1 to 8 tubes parallel processing
NGS Sample Volumes 5 to 320 µl
Recommended Batch Size 8 to 96 samples
Covaris Consumables Individual microTUBEs, 8 microTUBE strips (rack required), 96 microTUBE plate, 8 AFA-TUBE TPX Strip, 96 AFA-TUBE TPX plate (with RFID), miniTUBEs, milliTUBEs
Upgrade Potential Yes
Associated Accessories L-Series Accessories


Key Features:

  • Automated workflows with full robotic integration
  • Powered by AFA-energetics®
  • Multiple isothermal energy delivery modes
  • Broad temperature range at high power



  • Accurate, reproducible, and robust sample preparation
  • Tuneable, non-contact processing
  • Simplify highly complex workflows
  • Multiple applications: nanoparticle formulation, microbe lysis, and hydrophobic compound dissolution


Quick Guides:

Quick Guide: DNA Shearing with LE220-plus/LE220R-plus/LE220Rsc

RNA Shearing with S, E, and LE-Series Focused-ultrasonicators

TruSight Tumor 170 DNA Shearing Quick Guide


E220 & LE220 (-plus, R-plus, Rsc) Setup & Instruction Manual

LE220 (-plus, R-plus, and Rsc) Setup & Instruction Manual


High Molecular Weight DNA Extraction and Purification from Whole Blood - Fully-automatable and High-Throughput

Novel, Automated Co-extraction of High-quality DNA and RNA from a Single FFPE Sample


LE220R-plus Flyer

Covaris Automation Platform Solutions for Pre-analytical Sample Preparation

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